Nucific Bio X4 Reviews 2024: Review From Real Users

Nucific Bio X4 combines 4 highly potent blends that support overall body wellness as well as actively improve weight loss. BIO-X4 contains 12 billion CFUs, from 5 powerful Lactobacillus and Bifidobacterium probiotic strains, to help ensure smoother, more comfortable digestion. This scientifically formulated supplement is backed by extensive research and manufactured using high-quality ingredients. Discover the potential benefits of Nucific Bio X4 and embark on a journey toward better gut health and overall well-being.

Has the ever-increasing pursuit of daily deadlines and targets left you with improper gut health and untimely cravings?

We feel that Nucific Bio X4 is reliable as a dietary supplement that cures these and many other digestive functions.

Let us unravel the various benefits of this probiotic supplement as we go through a dense review of the same.


In recent times, there has been a visible surge in cases of gastrointestinal diseases across the globe.

If one goes by a global study then, it has been observed that almost 40% of adults worldwide are diagnosed with one of many functional gastrointestinal disorders (FGIDs).

Some of the most common and prominent symptoms of gastrointestinal malfunctions are heartburn, vomiting, nausea, peptic ulcer, etc.

However, a common and highly recommended remedy to cure such gastrointestinal disorders is to regulate the germination of gut bacteria (also known as digestive enzymes).

These enzymes play a crucial role in performing functions such as breaking down proteins, lipids, etc., and help in the degradation of fats.

By supplementing these enzymes through probiotic medications, several digestive, pancreatic, and lactose-related dysfunctions can be resolved and supported effectively.

What is Nucific Bio X4?

Nucific Bio X4 is a 4-in-1 health supplement for weight management. This product helps optimize your digestive system by working from the inside out to help you cut weight and give you a good feeling.

Each capsule is packed with a blend of nutrients that ensure balance in your digestive system, curbs your cravings for food and supercharges your metabolism and supports healthy weight loss.

Bio X4 is gluten-free, allergen-free, and vegetarian-friendly.

We have recently reviewed Bio X4 as one of the fastest-growing probiotic weight management supplements on the market today.

In the full review below, we’ll examine the science, statistics, and real customer experiences with the product so that you can determine if it’s right for you.

Is Bio X4 any good?

After taking the Nucific Bio X4 supplement for 3 months, many users confirmed that it really improves your digestion and energy levels, and the pounds just drop off. In those important ways, the product was beneficial.

Who Requires Bio-X4?

Bio-X4 can aid anybody who wants to lose weight healthfully without using harmful prescription meds or impossible-to-follow diets.

If you are searching for a proper Bio X4 review, then you should definitely read this review till the end.

Bio X4

Nucific Bio X4 4-in-1 Supplement – Image/Wellness Digest

What are the Benefits of Nucific Bio X4

By and large, the ingredients present in Nucific Bio X4 provide you with the following four major benefits-

  • Managing Cravings: With its special blend of Caralluma Fimbriata, Nucific Bio X4 helps you manage your untimely cravings.The nutrient is known for its properties as an appetite suppressant, that assists your body in the proper absorption of proteins; leaving you full and feeling healthy.
  • Weight Management: Nucific Bio X4 comes with compounds such as EGCG which ensure that the body weight is in constant check and control since they assist in the proper breakdown and regulation of excess body fat and help increase metabolism for the same.
  • Smooth Digestion: Amylase, lipase, and bromelain are some of the prominent enzymes used in Nucific Bio X4 which provide you with better and improved gut health and facilitate smooth digestion by helping the gut bacteria in proper breakdown of food.
  • Improved Metabolism: The enzymes in the supplement ensure proper regulation of gut bacteria, which play a vital role in maintaining body metabolism and in other vital processes such as processing and absorbing essential bodily proteins and other nutrients that are integral for the development of the body.


Nucific BIO-X4 – Key Facts

Benefits Improves Digestive Health, Energy, Immune Support, Promotes Weight Loss, Boosts Metabolism
Ingredients Probiotics, Digestive Enzymes, Green Tea Extract, and more
Discounts Up to 10% Off
Company Nucific
Form Capsule
Unit Count 90.00 Count
Age Group Adult
Gender Unisex

Bio X4 Ingredients: What Does Bio X4 Claim To Do?

Many of the ingredients in Bio-X4 are scientifically effective. It consists of four proprietary blends:

  • Weight Management Blend (100mg)
  • Craving Control Blend (166 mg)
  • Digestive Enzyme Blend (43 mg)
  • Probiotic Blend (4 billion CPU/capsule)

Supplement Facts

serving size : 1 capsules
serving per container: 90
Amount per serving % Daily Value
Probiotic Blend:

Lactobacillus Blend: L. acidophilus,

L. rhamnosus, L. plantarum

Bi dobacterium Blend: B. lactis, B. animalis

4 Billion CFU/Capsule **
Digestive Enzyme Blend:

Amylase (from Aspergillus Oryzae), Bromelain,

Lipase (from Rhizopus Oryzae)

43 mg **
Weight Management Blend:

Green Tea Extract (50% EGCG)

100 mg **
Craving Control Blend:

Slimaluma (Caralluma Fimbriata Extract)

166 mg **

**Daily Value not established

† At time of manufacture

Other Ingredients: Vegetable Cellulose (capsule), Microcrystalline Cellulose, Stearic Acid, Silica

Slimaluma® is a registered trademark of Gencor

In order to best assess if these blends work, we’ll take a look at the ingredients below.

Lactobacillus Blend

The lactobacillus blend, which includes L. acidophilus, L. rhamnosus, and L. plantarum, assists in a smoother and more comfortable digestion process along with other enzyme blends present in the supplement.

Bifidobacterium Blend

The Bifidobacterium Blend includes B. lactis, and B. animalis which help in functions such as curbing diarrhea, alleviating lactose intolerance, and reducing symptoms of irritable bowel syndrome (IBS)

Digestive Enzyme Blend

The Digestive Enzyme Blend, comprising lipase, bromelain, and amylase is known to maintain proper gut health by facilitating proper breakdown of food and ensuring proper absorption of nutrients.

Caralluma Fimbriata

Caralluma Fimbriata, also known as Slimaluma, is known for its appetite suppressant properties and hence helps you control your untimely and unhealthy cravings. It also assists in reducing weight management issues.


EGCG or Epigallocatechin Gallate is a nutrient present in green tea that helps maintain cholesterol levels and helps in the prevention of metabolic syndrome.

How to Take Bio X4?

For the best results, take 1 capsule of Nucific Bio X4 with each meal – breakfast, lunch and dinner.

Bio X4

Best way to take Bio X4 – Image/Wellness Digest

Highlights, Pros & Cons of Nucific Bio X4

Bio X4

editor’s rating

5stars4.8 / 5.0


  • Third-party tested
  • 100% organic ingredients.
  • 12 Billion CFUs, and prebiotics
  • MFG in the USA

All the process mentioned on their websites are subject to change.

  • quality image
  • 4.9 /5


  • support image
  • 4.8 /5

    Support Research

  • reputation image
  • 4.9 /5


  • price image
  • 4.8 /5


  • Suppress the appetite.
  • Speed up the metabolism and promote fat burning.
  • Enhance digestive health.
  • Give you added energy.
  • Strengthen the immune system.
  • You have to take 3 capsules per day, which will be hard for some customers.
  • May results vary from user to user.
  • It takes about 2 months for optimal results.

What Are the Side Effects of Bio X4

Although Nucific Bio X4 is known to be effective in its functioning as a probiotic supplement, there are, however, a couple of things that must be adhered to, for better and more effective usage.

  • Regular Consumption: Ideally one must refrain from missing out on a dosage. Irregularities in consumption might affect the efficacy of the enzymes as it takes time to maintain the gut enzyme activity.
  • Allergic and Individually Varying Results: Also, the supplement might have differing effects due to specific allergic and other varying conditions. In such cases, personal physician’s advice must be taken and the supplements should be consumed accordingly.
  • Fixed Dosage: It must also be borne in mind that not more than six capsules must be consumed on a particular day. Users are advised to take one or at the most two pills with every meal, i.e. breakfast, lunch, and dinner.

How Does Bio X4 Work?

A healthy weight loss starts with healthy digestion. For this, Nucific Bio X4 has prioritized the Digestive Enzyme Blend at 43mgs enough to promote a healthy breakdown of food in the intestines.

The Probiotic Blend Powered on the other hand helps support healthy gut function and helps you stay free from gas and feeling well.

A review in ISRN Nutrition examined the general health properties and benefits of probiotics according to current research.

Last but not least, the presence of the Craving Control Blend and the Weight Management Blend both help improve weight loss by suppressing appetite and increase your energy levels to improve weight loss. Bio X4 is best appetite suppressants supplement for weight loss.

A general population sample study in the European Journal of Clinical Nutrition concluded that caffeine intake was positively correlated with successful maintenance of weight loss.

Want to find the best fat burner for you? Not sure if Bio X4 is what you’re looking for, then check out our list of the best on the market. Read More About Best Fat Burners

Nucific BIO X4 Review | (Video Credit: YouTube)

About the Brand

Bio X4 is manufactured by Nucific Company in partnership with Dr. Amy Lee. Lee is an American Certified Board of Internal Medicine, who also sits on two boards: The National Board of Physician Nutrition and Specialists, and The American Board of Obesity Medicine.

In addition, Dr. Lee is known for her commitment to looking for innovative and better ways of helping clients and people at home have the best health results. Founded in 2014, the company has their headquarters in Tarzana, California.

According to the Bio X4 reviews, the company offers various other products. These other products include:

Best Deals, Feature Product & Coupon

Bio X4 Features
  • It helps you manage cravings for junk food.
  • It supports weight loss right from the gut levels.
  • Helps boost the body’s metabolism rate for improved energy levels.
  • It helps support smooth digestion.
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Nucific Bio X4 Review

Bio X4

Nucific Bio X4 4-in-1 Supplement – Image/Wellness Digest

This supplement has received many positive reviews an indication that it works at its claims. Previous customers of this product have praised the product claiming that it has helped them achieve positive results in their weight loss journey.

There are those who said that they were able to notice increased energy levels and it curbed cravings for unhealthy food. Some said they experience smooth digestion and normal bowel movement while others were happy that they were able to cut down significant weight.

As mentioned earlier in the article, there are many Bio X4 Reviews on Amazon but the supplement is no longer sold there. Out of 8,559 Bio X4 Reviews Amazon, 51% of customers gave it 5-star review and only 13% left a 1-star BioX4 Amazon review.

There are over 1,390 BioX4 reviews on HighYa, giving the product an overall 4.3 rating out of 5. The majority of Bio X4 customer reviews are positive, praising the supplement for helping to regulate their digestive system, decrease bloating after eating, and even lose weight.

Here’s honest feedback from the real users after experiencing Nucific Bio X4.

NUCIFIC BIO X4 Probiotic Supplement Review | Chrissy From Philly | (Video Credit: YouTube)

According to the Nucific website, there are 3955 Bio X4 reviews, earning the product a total rating of 4.6 out of 5.

Here are some of the real Bio X4 reviews:

    Feel better almost immediately.

  • First thing I noticed was the painful bloating and gas was gone! Will continue to use. I highly Julie F.
  • It works

  • I believe that this product really helps with cravings it flattened my stomach and give me boost of more energy which is important seeing how I take lots of meds that make me too Chayo84
  • I like them so far

  • I really noticed a difference In my appetite control. One day accidentally forgot to take it and could tell! I just wish they were in stock!by Lauren Huite
  • Works great

  • I use this every day for gut health. Works Jodi Boyer
  • Did not do anything

  • Did not do thegardenweaver
  • Helping with my upset stomach

  • I wasn’t realizing any benefit from other probiotic products but tried this one and I am feeling better and slowly loosing weight. I’m continuing to purchase clifford yarosh
  • Great for my gut.

  • I have had to deal with lupus since 1997 DX. This really keeps my energy level up. Also good advice to optimize G. Lynd
  • Still waiting to see some results

  • Not working like they said it was going to doby Mac Mac
  • Increased energy immediately.

  • Just felt better immediately. Increased my energy level significantly. This is my first attempt at something other than prescriptions. Will keep using for several months and see how things Diane Arnold
  • Stop the craving

  • This product really helps reduce the craving for junk food . I’ve only been using it a few day but I can tell the difference Maureen Dragges
  • Doesn’t work as specified

  • I took pills for several weeks it didn’t help me with curving appetite, going regular, or weight loss. Not recommended. And.. return not Ingrid A. Jimenez
  • Digestion system improved

  • Helping the Digestion Dov milinki

*Results may vary by individual.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Pricing & Money Back Guarantee

Nucific Bio X4 comes in three variants and can be ordered from the official Nucific website. For every order, there are no shipping charges applied and users can choose from the following three options-

Supply Price Membership Capsules
One Month $49.00 $44.00 90 capsules
Two Months $129.00 $114.00 180 capsules
Three Months $240.00 $216.00 270 capsules

As a brand, Nucific provides a 90 Days Money Back Guarantee on Nucific Bio X4. So, feel free to purchase and try the supplement at your convenience, and in case of any adverse reaction or allergic intolerance, consider returning the product for a refund.

Bio X4 Alternatives

After reading a review on Bio X4, sometimes you may wonder if there are alternatives to this Nucific weight management probiotic supplement. Below are some of the options you can consider using as alternatives.

Final Thought

Probiotics are currently rising into great prominence as gastric problems become more common among today’s population.

However, with myriad options in the market for the same product, what becomes crucial is how brands can add value to their supplements by making them more effective as well as ensuring their efficacy in treating various other symptoms.

With its digestive and weight management properties, Nucific Bio X4 is a probiotic alternative that is meant to boost your overall well-being as well as help you manage your cravings and weight loss goals.

If considered as an option, it might help you by boosting your digestive performance and thereby bringing about a balance in your gut health.

Bio X4 FAQ

Since our initial review, we have received a few additional questions about Nucific Bio X4. Here are the answers to the most common questions.

Q: How Much Does Bio X4 Cost?
A: Nucific Bio X4 is available for purchase on the official website, as well as from other online retailers like Amazon or Walmart. They offer discounts if you become a VIP, and also if you buy in bulk. However, as it is a supplement, this product is not eligible for HSA, FSA, or insurance as forms of payment. Here are the Bio X4 prices:

Supply Price Membership Capsules
One Month $49.00 $44.00 90 capsules
Two Months $129.00 $114.00 180 capsules
Three Months $240.00 $216.00 270 capsules
Q: How long does a bottle of Bio X4 last?
A: A bottle of Bio X4 contains 90 capsules, lasting 30 days if taken as recommended (3 capsules per day).
Q: Can you take Bio X4 without food?
A: For best results, take 1 capsule of Bio X4 with each meal – breakfast, lunch, and dinner.
Q: How many pills in a bottle of Bio X4?
A: There are 90 capsules in a bottle of Bio X4.
Q: What are the health benefits of Bio X4?
A: Bio X4 manages cravings, supports weight loss, boosts metabolism, and ensures smooth digestion.
Q: When should I use Bio X4?
A: Use Bio X4 with each meal – breakfast, lunch, and dinner for optimal results.
Q: What are the side effects of Bio X4?
A: Irregular consumption may affect efficacy. Some may experience allergic reactions. Do not exceed six capsules a day.
Q: How much does Nucific Bio X4 cost per month?
A: A one-month supply of Nucific Bio X4 costs $49.00, with a membership price of $44.00.
Q: What are the ingredients in Nucific Bio X4?
A: Bio X4 contains probiotics, digestive enzymes, green tea extract, Caralluma Fimbriata, and more, designed for digestion and weight management.

At Wellness Digest, our sourcing guidelines are strict and we only use primary references for our articles including peer-reviewed studies, academic research institutions, and medical associations. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. Gorbach SL. Microbiology of the Gastrointestinal Tract. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 95. Available from:
  2. Di Cerbo A, Palmieri B, Aponte M, Morales-Medina JC, Iannitti T. Mechanisms and therapeutic effectiveness of lactobacilli. J Clin Pathol. 2016 Mar;69(3):187-203. doi: 10.1136/jclinpath-2015-202976. Epub 2015 Nov 17. PMID: 26578541; PMCID: PMC4789713.
  3. Human Α-Amylase And Starch Digestion: An Interesting Marriage:
  4. Brusaferro A, Cozzali R, Orabona C, Biscarini A, Farinelli E, Cavalli E, Grohmann U, Principi N, Esposito S. Is It Time to Use Probiotics to Prevent or Treat Obesity? Nutrients. 2018 Nov 1;10(11):1613. doi: 10.3390/nu10111613. PMID: 30388851; PMCID: PMC6266556.
  5. Forester SC, Lambert JD. The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Mol Nutr Food Res. 2011 Jun;55(6):844-54. doi: 10.1002/mnfr.201000641. Epub 2011 May 2. PMID: 21538850; PMCID: PMC3679539.
  6. Kechagia M, Basoulis D, Konstantopoulou S, Dimitriadi D, Gyftopoulou K, Skarmoutsou N, Fakiri EM. Health benefits of probiotics: a review. ISRN Nutr. 2013 Jan 2;2013:481651. doi: 10.5402/2013/481651. PMID: 24959545; PMCID: PMC4045285.
  7. Icken D, Feller S, Engeli S, Mayr A, Müller A, Hilbert A, de Zwaan M. Caffeine intake is related to successful weight loss maintenance. Eur J Clin Nutr. 2016 Apr;70(4):532-4. doi: 10.1038/ejcn.2015.183. Epub 2015 Nov 11. PMID: 26554757.
  8. Wang S, Chen L, Yang H, Gu J, Wang J, Ren F. Regular intake of white kidney beans extract (Phaseolus vulgaris L.) induces weight loss compared to placebo in obese human subjects. Food Sci Nutr. 2020 Feb 5;8(3):1315-1324. doi: 10.1002/fsn3.1299. Erratum in: Food Sci Nutr. 2020 Sep 30;8(10):5763. PMID: 32180941; PMCID: PMC7063375.
  9. Piaggi P. Metabolic Determinants of Weight Gain in Humans. Obesity (Silver Spring). 2019 May;27(5):691-699. doi: 10.1002/oby.22456. PMID: 31012296; PMCID: PMC6481299.
  10. Jungersen, M., Wind, A., Johansen, E., Christensen, J., Stuer-Lauridsen, B. and Eskesen, D. (2014). The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®. Microorganisms, [online] 2(2), pp.92–110. Available at: [Accessed 29 Oct. 2021].
  11. Gut reaction: A limited role for digestive enzyme supplements
  12. Fermented Dairy Products, Probiotic Supplementation, and Cardiometabolic Diseases: A Systematic Review and Meta-analysis
  13. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial
  14. Probiotics and Gastrointestinal Conditions: An Overview of Evidence from the Cochrane Collaboration - PMC:
  15. Hodgson AB, Randell RK, Jeukendrup AE. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Adv Nutr. 2013 Mar 1;4(2):129-40. doi: 10.3945/an.112.003269. PMID: 23493529; PMCID: PMC3649093.
  16. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial - PubMed:
  17. Nutrients | Free Full-Text | The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals | HTML:
  18. The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults - PMC:
  19. Effects of green tea extract on overweight and obese women with high levels of low density-lipoprotein-cholesterol (LDL-C): a randomised, double-blind, and cross-over placebo-controlled clinical trial | BMC Complementary Medicine and Therapies | Full Text:
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Customer Reviews for Bio-X4

Nucific Bio X4
Customer Reviews & Ratings
Review this Product Write a Review
  1. Michael Conway

    Your Rating:

    Bio x4 worked for me.
    I’ve been using Bio-X4 for a few years. It’s definitely improved my digestion and helped me lose weight. Inside and out, I feel and look better. I would definitely recommend Bio X4 to anyone seeking a healthier lifestyle.
  2. Mary Ezzard

    Your Rating:

    Bio X4 is a game changer
    I’m impressed with Nucific Bio X4 supplement! It has helped me reduce bloating, cravings, and weight. It shows changes in the second and third week already.
    Highly recommended!
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